Effect of Cerebrolysin on Cognitive Functioning Following Brain Injury

Author/Year/ Country/Study Design/N

Methods

Outcomes

Alvarez et al. (2003)
Spain
Pre-Post
N=20

Population: TBI; Mean Age=30.1yr; Gender: Male=15, Female=5; Mean GCS=6.1; Time Post Injury Range=23-1107d.
Treatment: Patients with TBI received a total of 20 intravenous infusions of cerebrolysin solution (30mL/infusion) over 4wk. Assessments were made at baseline, during treatment, and after the 4wk treatment period.
Outcome Measure: Syndrome Kurztest (SKT), electroencephalogram (EEG)/brain mapping recordings, and Glasgow Outcome Scale (GOS).

  1. Compared to baseline, patients with TBI showed a significant decrease in slow bioelectrical activity frequencies (delta: p<0.01; theta: p<0.05), and a significant increase in fast frequencies (beta: p<0.01) after receiving cerebrolysin, suggesting improvement in brain bioelectrical activity.
  2. Significant improvements in SKT performance was noted from pre to post treatment (15.9±2.4 vs.12.0±2.1; p<0.01).
  3. GOS scores significantly improved from pre to post treatment (3.7±0.3 vs. 3.95±0.3; p<0.05).