Metoclopramide and Enteral Nutrition

Author/Year/ Country/Study design/PEDro Score/ N

 

Methods

 

Outcomes

Nursal et al. (2007)
USA
RCT
PEDro=9
N=19

 

Population: TBI; Control Group (n=9): Mean Age=43yr; Gender: Male=8, Female=1; Mean GCS Score=8.9. Treatment Group (n=10): Mean Age=43.8yr; Gender: Male=8, Female=2; Mean GCS Score=7.7.
Treatment: Patients in the treatment group were administered 10mg (2 mL) IV metoclopramide 3×/d for 5d. The control group received the same volume of control saline solution for the same duration.
Outcome Measure: Paracetamol absorption test, amount of calories supplied, intolerance and/or complication rates.

  1. Amount of oral/enteral calories in relation to the total number of calories received during the first 5 d was higher for those in the control group (p=0.043).
  2. There were no differences between the groups in both feeding intolerance and complications rates (p=0.543 and p=0.930, respectively).
  3. There was no significant difference between the groups when looking at the results of the paracetamol absorption test.
  4. When looking at absorption parameters, those in the treatment group had levels that were slightly more pronounced than those in the control group.

PEDro = Physiotherapy Evidence Database rating scale score (Moseley et al., 2002).