What type of medication is carbamazepine?
Carbamazepine inhibits voltage-dependent neuronal sodium channels 31. As indicated in the CPS, carbamazepine blocks the physiological action of acetylcholine and has a moderate anticholinergic action that is responsible for some of its side effects 32.
Has been shown to successfully treat various seizure disorders and obsessive compulsive disorder.
- Has been suggested that carbamazepine may be effective in treating aggressive behaviour post TBI.
What evidence is there that carbamazepine is effective in treating behavioral issues post ABI?
- There is very limited evidence that Carbamazepine is effective in treating behavioural issues post ABI.
It is believed that carbamazepine may be an effective alternative to lithium.
- Azouvi et al.33showed that agitation and behaviour initially improved with carbamazepine but that improvement was much less significant over time.