What is the evidence supporting the efficacy of methylphenidate for aggressive behavior post ABI?

  1. There is Level 2 evidence to suggest that treatment with methylphenidate following brain injury can significantly reduce anger as measured using several anger outcome measures.
  2. Overall, it has been shown that anger may be reduced following brain injury with methylphenidate treatment.
  • Methylphenidate (in one RCT) has been shown to help to significantly reduce anger following brain injury as demonstrated using several anger outcome measures 37.
  • Despite the differences between the groups on one anger measure, a significant group main effect for the drug treatment was demonstrated.