Zinc Supplementation in patients with ABI

Author/Year/ Country/Study design/PEDro Score/N





Young et al. (1996)


Population: Head injury; Intervention Group (n=33): Mean Age=34.6yr; Gender: Male=27, Female=6; Mean GCS Score=6.4. Control Group (n=35): Mean Age=35.9yr; Gender: Male=28, Female=7; Mean GCS Score=6.6.
Treatment: Patients were randomly assigned to receive either zinc at a standard level (2.5 mg) or zinc-supplementation (12 mg) for 15 d. After 15 d, oral zinc (168 mg zinc gluconate, 22 mg elemental zinc) or matching placebo tablet were given for a total of 3mo.
Outcome Measure: Glasgow Coma Scale (GCS), mortality, zinc concentration, serum pre-albumin levels, retinol-binding protein (RBP) concentrations.

  1. There was no significant difference in 1 mo mortality rates between groups (p=0.09).
  2. GCS scores of the zinc-supplemented group were greater than the adjusted mean GCS score of the standard group at day 28 (p=0.03).
  3. Mean serum pre-albumin levels and mean RBP concentrations were significantly higher in the zinc-supplementation group at 3 wk post-injury (p=0.003 and p=0.01, respectively).
  4. The groups were not different in serum zinc concentration, weight, energy expenditure, or total urinary nitrogen excretion after admission.
  5. The mean 24 hr urine zinc levels were significantly greater in the zinc-supplemented group at days 2 (p = 0.0001) and 10 (p = 0.01).

PEDro = Physiotherapy Evidence Database rating scale score (Moseley et al., 2002).