Banos et al. (2010)
Population: TBI. Treatment group (n=49): Gender: Male=39, Female=10; Mean Age=35.3yr; Mean Time Post Injury=21.5d; Mean GCS=5.8. Placebo group (n=50): Gender: Male=33, Female=17; Mean Age=34.5yr; Mean Time Post Injury=19.2d; Mean GCS=5.8.
Treatment: Participants were randomized to either the treatment group which took sertraline daily (50mg) or placebo. Patients were assessed at 3, 6 and 12 months.
Outcome Measure: Wechsler Memory Index (Wechsler Adult Intelligence Scale III), Symbol-Digit Modalities Test, Logical Memory, Trial Making Test and 64-item Wisconsin Card Sorting Test.
- More subjects in the treatment group dropped out at each time point.
- Those in the placebo groups at the 6th and 12th month assessment period were older than the control group and had higher GCS.
- Overall, there were no significant differences between the two groups on any of the cognitive measures.