3.3.4.10 Methotrimeprazine (Nozinan)

What type of medication is methotrimeprazine?

1.    Methotrimeprazine (Nozinan) is a psychotropic medication with antipsychotic (mediated by dopamine blocking), tranquilizing,and analgesic properties.  It appears to have an effect on opiate (pain) receptors as well.

What evidence is there that methotrimeprazine is effective in treating behavioral issues post ABI?

  1. There is Level 4 evidence that in most cases methotrimeprazine is safe and effective for controlling agitation after ABI.
  • Maryniak et al. 47looked at the affect methotrimeprazine (MTZ) would have on patients being treated for severe agitation post ABI andfound that in most cases MTZ was both safe and effective for controlling agitation.

For more details please seeERABI/Mental Health Issue Post ABI.