3.3.4.11 Lithium Carbonate

Lithium carbonate is most commonly used for bipolar disorder; however it has also been used to treat hypomania and affective instability in individuals with brain injuries 48.

What evidence is there that lithium carbonate is effective in treating aggressive behavior?

1.    It has been suggested that lithium carbonate is useful for treating evidence behavior and affective instability after ABI.  However, it has the potential to cause neurotoxicity.

  • The authors in one study of 10 brain injured patients being treated for aggressive behavior or affective instability with lithium carbonate, results showed lithium carbonate can be useful for treating aggressive behavior and affective instability after brain injury, but it can also cause neurotoxicity 48.

For a more detailed discussion on these studies please see ERABI/Mental Health Issues Post ABI.