3.3.4.3 Carbamazepine (Tegretol)

What type of medication is carbamazepine?

  1. Carbamazepine inhibits voltage-dependent neuronal sodium channels 31.  As indicated in the CPS, carbamazepine blocks the physiological action of acetylcholine and has a moderate anticholinergic action that is responsible for some of its side effects 32.
     
  2. Has been shown to successfully treat various seizure disorders and obsessive compulsive disorder.
     
  3. Has been suggested that carbamazepine may be effective in treating aggressive behaviour post TBI.

What evidence is there that carbamazepine is effective in treating behavioral issues post ABI?

  1. There is very limited evidence that Carbamazepine is effective in treating behavioural issues post ABI.
  • It is believed that carbamazepine may be an effective alternative to lithium.
     
  • Azouvi et al.33showed that agitation and behaviour initially improved with carbamazepine but that improvement was much less significant over time.