Young et al. (1996)
Population: Head injury; Intervention Group (n=33): Mean Age=34.6yr; Gender: Male=27, Female=6; Mean GCS Score=6.4. Control Group (n=35): Mean Age=35.9yr; Gender: Male=28, Female=7; Mean GCS Score=6.6.
Treatment: Patients were randomly assigned to receive either zinc at a standard level (2.5 mg) or zinc-supplementation (12 mg) for 15 d. After 15 d, oral zinc (168 mg zinc gluconate, 22 mg elemental zinc) or matching placebo tablet were given for a total of 3mo.
Outcome Measure: Glasgow Coma Scale (GCS), mortality, zinc concentration, serum pre-albumin levels, retinol-binding protein (RBP) concentrations.
- There was no significant difference in 1 mo mortality rates between groups (p=0.09).
- GCS scores of the zinc-supplemented group were greater than the adjusted mean GCS score of the standard group at day 28 (p=0.03).
- Mean serum pre-albumin levels and mean RBP concentrations were significantly higher in the zinc-supplementation group at 3 wk post-injury (p=0.003 and p=0.01, respectively).
- The groups were not different in serum zinc concentration, weight, energy expenditure, or total urinary nitrogen excretion after admission.
- The mean 24 hr urine zinc levels were significantly greater in the zinc-supplemented group at days 2 (p = 0.0001) and 10 (p = 0.01).